Abstract: The hydroconversion of Tahe vacuum residue (THVR) was studied by using autoclave to simulate the reaction process in slurry-bed reactor. The effects of reaction conditions on coke formation rate, conversion and product distribution during THVR hydroconversion were investigated. Experimental results show that the conversion and coke yield increase with the reaction temperature; the increase of initial hydrogen pressure can suppress coke formation significantly, conversion decreases firstly, when the initial hydrogen pressure is more than 8 MPa, it increases slightly; prolonging reaction time, both conversion and coke yield increase. The presence of catalyst can inhibit the reactions of coke formation effectively, yet cracking reactions are affected as well, so the amount of catalyst added should be optimized. By comprehensive consideration, the suitable reaction conditions are selected as follows: reaction temperature should not be more than 430 ℃, initial hydrogen pressure between 7—8 MPa, reaction time between 40—60 min and catalyst added amount in the range of 2 000—6 000 mg/kg.