Abstract: Membrane bioreactor (MBR) is applied in refining wastewater advanced treatment for water reuse at SINOPEC Hainan Petrochemical Company. Using domestic PVDF hollow fiber membrane to substitute the import one, the quality of treated effluent still can meet the quality requirements for reuse as makeup of circulating water, having average COD of 41 mg/L, average hydrocarbons and NH3-N of below 1 mg/L and 0.81 mg/L, respectively. Keeping membrane flux less than the design value could slow down the rate of membrane fouling and maintain a stable membrane flux. However, in order to keep the domestic PVDF hollow fiber membrane under good conditions, proper online cleaning and routine offline cleaning are essential, besides, retaining appropriate sludge concentration and discharging sludge regularly are also important.