Abstract: Titanium silicalite was hydrothermally synthesized with tetraethyl orthosilicate, tetrabutyl titanate and tetrapropyl ammonium hydroxide template. The structures of titanium silicalite were characterized by XRD, UV-Vis and TEM. The characterization results indicate that the samples prepared possess MFI structure and good crystallinity, and no non-frame anatase type TiO2 is found. The performance of catalytic epoxidation of propylene by titanium silicalite was studied in a slurry bed reactor using hydrogen peroxide as oxidant and methanol as solvent. Under the optimized conditions (1.5 g titanium silicalite, 150 mL methanol, 25 mL 30% H2O2, 0.2 mL 2.5% NaHCO3, propylene flow 1 L/min, at 0.2 MPa and 55 °C，reaction time of 1 h), the selectivity and yield of propylene oxide are 98.7%, 87.6%, respectively.