Abstract: On the basis of inferior residue hydrotreating mechanism, a novel hydrodemetallization catalyst RDM-36 was developed by developing new alumina material to optimize catalyst pore structure, by using new active component loading method to improve catalyst metal capacity and by modifying surface properties to promote catalyst stability. The new catalyst possesses high activity to remove metal and increase conversion of asphaltene. The stability test shows that the residue having vanadium and nickel content as high as about 200?g/g can be stably hydrotreated by grading series catalyst with RDM-36. It is helpful to increase adaptability to feedstock for RDS unit.