Abstract: It is very meaningful to optimize the hydrocracking process for obtaining high quality fuels from FT wax. After the main factors that have significant effect on the hydrocracking conversion of FT wax were determined through conditional experiment, the central composite design method was used to investigate the influence of single items, interaction items and square items of these major factors on the wax conversion and middle fraction content of products. In order to test the optimum operating conditions, full quadratic models describing the conversion of FT wax and the content of C10-22 fraction of the hydrocracking products were determined based on MATLAB. Results indicate that temperature has a significant effect on the wax conversion, followed by liquid space velocity, pressure and H2/Wax ratio; furthermore, temperature and H2/Wax ratio have a positive effect on the wax conversion while pressure and space velocity have an inverse relationship with conversion rate．The interaction items of temperature and pressure, space velocity and pressure also play a major role in the hydrocracking process．The middle fraction content may reach maximal value under the following conditions: 377 ℃, 5.0 MPa, 1.95 h-1 of WHSV, 820 V/V of H2/Wax ratio.