Abstract: Ni/ZnO-SiO2-Al2O3 adsorbents were prepared by impregnation and wet mixing methods，respectively. XRD and mercury porosimeter were adopted to characterize the crystal structure of the adsorbent s. A fixed bed reactor was used to investigate the desulfurization performance of hydrogasoline with different adsorbents. The results show that the adsorbents prepared by wet mixing method have a higher special surface area and similar pore volume and better desulfurization performance compared with the adsorbents prepared by impregnation method. The desulfurization experiment using the hydrogasoline from Shandong Hengyuan petrochemical company as feed indicates that the content of sulfur is decreased from 69 μg/g to 10μg/g, while the octane number of the gasoline produced decreases by only 0.6 and the sulfur capacity of the adsorbent is up to 9.98 wt% at the conditions of 350 ℃, 2.0 MPa, LHSV of 7.0 h-1, hydrogen to gasoline volume ratio of 60:1. The adsorbent has a good adaptability to various hydrogasolines. The desulfurization performance of the adsorbent regenerated for 3 times is the same as that of the fresh one.