Abstract: Asphaltene exists in residue in form of large molecular aggregates and it is difficult to diffuse and react in catalyst microporous. Tahe atmosphere residue was used as test material to see the effect of stirring on hydrotreatment results. It is found that by addition of a constant-temperature stirring process at 373K for 1h before the residue hydro-treatment, the diffusibility of asphaltene in catalyst microporous is improved due to the depolymerization and dispersion of decalin for asphaltene. Compared with the results without stirring, the stirring process can make asphaltene conversion increase by 15%, the coke yield decrease by 2.5%, and the hydrotreated residue amount also decreases. The four components of hydrotreated residue undergo a significant change: the saturate, aromatic, and resin are increased. The removal of sulfur and nitrogen is improved to different degrees. It is demonstrated that the structure state of asphaltene is changed by stirring and that the addition of the stirring step is beneficial to hydroconversion of asphaltene.