Abstract: TiO2/SBA-15 photocatalysts were synthesized by impregnation method using tetra-n-butyl titanate (TnBT) as titanium source. The properties of the catalyst were characterized by XRD and BET. The results show that TiO2/SBA-15 catalyst keeps the structure of the support SBA-15. The photocatalytic oxidative desulfurization performance of the catalyst was investigated using thiophene isooctane solution as a simulated oil and H2O2 as an oxidant under UV light irradiation. The process conditions of the reaction were determined by static experiment. The optimum reaction conditions are as follows: 50 ℃，120 min, catalyst dosage of 2 g/L(feed), the O/S molar ratio of 8.5:1. Under the conditions, the desulfurizition rate of simulated oil is up to 88.2%, indicating that TiO2/SBA-15 has a good performance of photocatalytic oxidation desulfurization.