Abstract: A new RFCC catalyst CRM-200 with disordered mesoporous silica-alumina material (JSA), which possesses properties of high hydrothermal stability, macromolecular cracking ability, good coke selectivity, low cost and easy to industrialization, was used in a RFCC unit of Qingdao Anbang Company. The industrial application results reveal that CRM-200 shows much higher cracking activity, the total liquid yield increases about 1.86%, the yield of slurry and coke decreases 0.92 percentage point and 1.59 percentage points, respectively. The distribution and properties of cracking products are improved. The processing capacity and recycle oil increases. The resid-ratio increases from 69.92% to 83.34%. The operation condition is optimized, at the same time the catalyst consumption reduces about 1 kg/t.