Abstract: The fresh ultra-deep hydrodesulfurization catalysts RS2100/RS2110 (developped by SINOPEC Research Institute of Petroleum Processing) and regenerated FHUDS catalyst series (developped by SINOPEC Dalian(Fushun) Research Institute of Petroleum Processing) were used in a 1.67 Mt/a hydrotreating unit processing mixed feedstock of coker gasoline, coker diesel and atmospheric gas oil in SINOPEC Tahe Refinery & Chemical Company. The national VI standard diesel was obtained with flash point (closed) of 68℃，S content of 3.2 μg/g，nitrogen content of 0.67 μg/g， cetane number of 52，and poly-aromatic hydrocarbons content of 2.9 %. However, the deactivation rate of catalysts was to 24.0 ℃/a within half a year. After adjusting the temperature distribution of two reactors，raw material composition as well as the sulfur content of products， the catalyst deactivation rate was reduced to less than 14.4 ℃/a，the pressure drop of reactors was 0.4 MPa, and the maximum temperature of reactor bed was less than 390 ℃, indicating a good stability of the catalysts system. The catalysts can meet the need for long term operation.

Key words: hydrogenation catalysts, coker gasoline, coker diesel, hydrodesulfurization, operation optimization, China national standard Ⅵ diesel