Abstract: Taking a typical absorption and stabilization system with four towers as research object, by comparing the calculation results from PRO/Ⅱsimulation software and the calibration data of the practical unit, parameters in the simulation are determined and SRK method is adopted to optimize simulation. In the premise of the specific qualities of dry gas, LPG and gasoline, the effect of operation parameters on the energy consumption and absorption results is studied, and the optimized operation parameters are obtained as follows: a complementary absorbent flow rate of 29 t/h, a system operation pressure of 1.4 MPa, the flow rate ratio of hot and cold feeds for the desorption tower is 7 to 3, and the feed inlet location and temperature of the stabilization tower is at 12th theory tray and 138 ℃, respectively. The simulation results demonstrate that by optimizing operation parameters, the cooling duty and heating duty of the unit is reduced about 4% and 5%, respectively.