Abstract: The industrial application of two C8 aromatics isomerization catalysts, RIC-200 developed by Research Institute of Petroleum Processing and an imported catalyst represented the advanced world level, was introduced. The start-up, performance test and long-term operation of these two catalysts were compared. Industrial application results show that these two catalysts all exhibit good isomerization activity and stability; the conversion of ethylbenzene, C8 hydrocarbons yield and selectivity of RIC-200 are slightly better than those of the imported catalyst. Besides, RIC-200 catalyst is in reduced state, thus its start-up procedure is simple and the start-up period is shorten; its operation risk is low and more stable due to without water injection to adjust catalyst activity during operation.