Abstract: The configuration comparison of a new 13 million tons per year refinery is selected as a case study. Flexi-coking technology is introduced and supposed to replace the combined process of delayed coking plus partial oxidization for hydrogen production, so total flow chart, utility engineering, costs of investment and operation might change accordingly. Likewise, the influence of flexi-coking technology on new refinery planning and designing is analyzed and summarized briefly. On the whole, flexi-coking technology is wide adaptable to residue feeds, and also it can generate low heat value fuel gas to make up the shortage of fuel for refinery, however, since no domestic existing unit is running, it is always hard for refinery to make decision without hesitation.