Abstract: The commercial application of RL-2 Lube hydrotreating catalyst in SINOPEC Jingmen Company is introduced. The commercial operation demonstrates that the catalyst has excellent reactivity, good selective ring-opening performance and good activity stability. The deactivation rate of the catalyst is only 3.67℃/a. The results of the stable operation for three years indicate that RL-2 catalyst can be used for the production of HVI Ⅱ group No. 10 lube base oil or even higher grade.