Abstract: Silicon-containing pseudo-boehmites were prepared with kaolin as silicon source and then used to prepare the related catalysts. Orthogonal design experiments were applied to investigate the effect of the concentration of sodium meta-aluminate and aluminum sulfate, reaction temperature, pH on the characteristics of the silicon-containing pseudo-boehmite and catalysts. The samples were characterized by XRD, BET, FT-IR, and SEM. The evaluation tests of residual hydrogenation activity were conducted. The results show that the silicon-containing pseudo-boehmites are easily prepared with lower cost. The pore volume of silicon-containing alumina is 0.866 cm3/ g, and the proportion of large pore (pore diameter more than 20 nm) can reach 52.63 %. The particle diameter can reach maximum 54.14 μm. Compared with the silicon-containing alumina prepared by carbonation method and aluminum sulfate method, the B/L acid value of the support by new method is higher 6.3% and 3.5%, respectively. The catalyst prepared by the new method has a good hydrogenation performance. At the similar removal rate of impurities, the conversion of residue above 500 ℃ is 14.5% and 11.6%, respectively higher than that of the carbonation method and aluminum sulfate method.