Abstract: Bring titania whisker with pure anatase crystal structure into alumina, the hydrodesulfurization activity of Ni-Mo/γ-Al2O3 catalyst can be increased. The characterizations of Raman spectrum and H2-TPR indicate that titania whisker can weak the interaction between alumina and active components, which favors the active metal molybdenum to form octahedral species, resulting in higher activity of the catalyst. When the content of titania whisker is beyond a certain rang, the catalyst activity is decreased due to the significant reduction of specific surface area.