Abstract: The RS-1100 catalyst has been applied in the 1.6 Mt/a diesel hydrorefining unit of SINOPEC Cangzhou Petrochemical Company. Industrial application results show that RS-1100 catalyst has excellent hydrodesulfurization activity though the feedstock quality is worse than that of design and the average reaction temperature is 22 ℃ lower than the design value. The product meets the national Ⅲ standard of diesel oil. The RS-1000 provides a powerful technical support for diesel quality upgrading.