Abstract: ZSM-5 was synthesized by seeded method and compared with that by using template. The sodium silicate was used as a silica source and the products were characterized by XRD, SEM and N2 adsorption. To obtain detailed information on the rules of synthesis process, the effect of crystallization time, crystallization temperature, n（H2O/SiO2）and the initial gel pH on ZSM-5 crystallinity were systematically studied. The results show that the prepared ZSM-5 with relative high crystallinity can be obtained successfully by seeded method at the conditions of crystallization time of 10～13 h，crystallization temperature of 180 ℃，gel pH of 9 under the fixed [n(H2O)/n(SiO2)] of 18. No differences are found in physical and chemical properties of ZSM-5 prepared by seeded method and template n-butylamine. The zeolites were tested in a micro fixed-bed reactor using Daqing vacuum gasoline oil (VGO) as a feed. The similar results are observed for the two zeolites.