Abstract: The domestic S-Zorb sorbent developed by Research Institute of Petroleum Process (RIPP) and produced by Sinopec Catalyst Nanjing branch was used in the 1.2Mt/a FCC gasoline desulfurization unit in Yanshan refinery. The industrial results indicate that the start-up operation is stable when all domestic sorbent is used in the reaction - regeneration system. When the feedstock is FCC gasoline, the runaway of reactor temperature can be avoided effectively by fine operation and sorbent pre-sulfidation. The domestic sorbent used shows high desulfurization activity for FCC gasoline. The sulfur content of gasoline product can be controlled below 8 μg / g, meeting the standard of Beijing V gasoline.