Abstract: The adsorption tests of quinoline in dodecane solution on silica gel by batch scale reactor were conducted. The influence of calcination temperature of silica gel and the adsorption temperature, adsorption time as well as regeneration on the denitrogenation was investigated. It is found that the Langmuir equation is more suitable for fitting the adsorption isotherm. The adsorption results show that silica gel calcined at 400℃ has a better adsorption performance of basic nitrogen compounds, and that under the adsorption conditions of 20℃, the adsorbent to oil ratio of 0. 03 g/g, and the reaction time of 30min, the best adsorption result (for 1500μg/g N sample, N removal >70%) can be obtained. The fact that the basic nitrogen removal keeps in more than 68% after multiple regenerations indicates the good regeneration ability of the silica gel.