Abstract: The effect of calcination temperature of support on physical structure and the performance of catalysts was studied. The support and catalysts were characterized by BET, TPR and TEM techniques. The carbon residue reduction (HDCCR) activity of hydrogenation catalyst was conducted using an autoclave. It is shown that with increasing calcination temperature, specific surface area of the support decreases, mean pore size enlarges, the number of –OH group on the support surface decreases，which weakens the interaction between metal and support. It is found that the calcination makes the structure of MoS2 slab change. With increasing calcination temperature, the slab size becomes larger, leading to a lower dispersion. The HDCCR activity of the catalyst reaches the best when the support is calcined at 600℃.