Abstract: A hydroisomerization catalyst was developed based on AEL zeolite. n-C12 and the hydrotreated 650SN furfural refined oil were used as feeds, respectively, to evaluate the hydroisomerization performance of the catalyst. The results show that the catalyst has better hydroisomerization activity and selectivity. When processing 650SN, the high quality group API III lube base oil is produced. The pour point of the base oil reaches -21℃, 6℃ lower than the reference catalyst, and heavy base oil yield reaches 62.79%, 5.55% higher than the reference one, which indicates that the hydroisomerization performance of the catalyst is better than the reference catalyst.