Abstract: Five kinds of MeAPO-5 molecular sieves containing Ce, Fe, Cr, Ti, and Sn, respectively were synthesized by hydrothermal method in the absence of HF. The successful synthesis of the MeAPO-5 molecular sieves was verified by the characterization of X-ray fluorescence spectrometry, N2 adsorption-desorption isotherm, XRD, FT-IR, and NMR of 31P and 27Al. The catalytic performance of the five MeAPO-5 molecular sieves in the cyclohexane oxidization reaction with air was investigated. Using the CeAPO-5molecular sieve, at the reaction conditions: 1.25 MPa and 165 ℃ for 0.5 h, the cyclohexane conversion is 10.9%, and the selectivity for cyclohexanol, cyclohexanone, and cyclohexylhydroperoxide is 40.0%, 29.3%, and 10.2%, respectively, and the total yield of the three products is up to 8.7%, which is evidently the highest among all MeAPO-5 molecular sieves tested, showing the CeAPO-5 molecular sieve is a more proper catalyst for the oxidizing reaction of cyclohexane with air.