Abstract: Solid superacid catalyst SO42-/TiO2-SnO2 was prepared by sol-gel method； The catalytic performance was evaluated by the esterification of acetic acid and n-butanol and the influences of preparation parameters on its catalytic properties were studied. These catalysts were characterized by IR, XRD and TG-DTA. The optimum preparation conditions for the catalyst SO42-/TiO2-SnO2 was: the mole ratio of titanium and tin 3∶1, impregnated with 2.0mol/L H2SO4, calcinated at 500℃ for 3 h。