Abstract: A non-mercury AuCl3-CuCl2/γ-Al2O3 catalyst was prepared by impregnation method using γ-Al2O3 as support. The catalytic properties for acetylene hydrogen chloride reaction were explored in a fixed bed reactor. The catalyst was characterized by SEM-EDS, FT-IR, inductively coupled plasma atomic emission spectrum and BET analysis to see the reason for catalyst deactivation. The results show that acetylene conversion reaches more than 97% and the vinyl chloride selectivity is more than 99% under the conditions of 150 ℃, 0.1 MPa, 120 h-1 ,V(HCl) : V(C2H2) = 1.05:1. However, the high activity can only keep for 3h. The analysis found that the carbon deposit on the catalyst surface is the main reason for the deactivation. It proved that the catalyst activity can be recovered to the fresh level after regeneration in air for 1h at 500 ℃.