Abstract: The deep catalytic oxidation desulfurization of model oil (thiophene/petroleum ether) was studied using Ag/γ-Al2O3 as catalyst and gaseous oxygen as oxidant. The catalyst was characterized by X-ray diffraction (XRD) and low temperature N₂-adsorption techniques. The effects of catalyst amount, reaction temperature and time, as well as extraction conditions on the oxidation desulfurization were investigated. Test results showed that using 20 mL of model oil, 0.12 g of catalyst, reacting at 70 ℃ for 50 min, the obtained material was extracted by methanol at 20 ℃ for 30 min with a solvent/oil volume ratio of 1, the rate of desulphurization reached 98.1 %. The kinetic study indicates that catalytic oxidation of thiophene is a pseudo first-order reaction, which could be expressed as k =0.049 45exp[－10 683.4/(RT)].