Abstract: The corrosion types of high pressure hydrogenation equipment and related effective protecting measures are introduced. Main equipment corrosion issues happened during the operation of two sets of high pressure hydrogenation units (residue hydrotreating and hydrocracking) in Hainan Petrochemical Company since startup, as well as the countermeasures are summarized, and some suggestions for operation and further improvement are proposed. From the years of production experiences, it can be seen that based on a proper design, optimum material selection and equipment manufacture, during the daily work, strengthening managements of process operation, equipment inspection and corrosion protection, a long-term safety and stable running of high pressure hydrogenation unit is truly possible.