Abstract: In this paper, some measures to prolong the service life of RN-10B hydrotreating catalyst in the gasoline and diesel fuel hydrotreating unit of SINOPEC Tahe Branch were introduced, such as monitoring the operation of feedstock filter, protecting feedstock and desalted water with inert gas, controlling the content of non-metallic/metallic inorganic compounds in feedstock, optimizing the hydrogen to oil ratio, adopting suitable catalyst and guard catalyst combination, properly adjusting the content of H2S in recycle hydrogen and the temperature of catalyst bed. Since applying these technical measures, till June 2011 the operation period of RN-10B catalyst was 501 d longer than the design value and the processing capacity of per unit catalyst was also higher than the design value (a 0.5 kt/kg increase).