Abstract: Three mature combined refining configurations, delayed coking+CFB, RDS+RFCC and DAU+IGCC, for processing high-sulfur inferior crudes are summarized, and the limitations of these configurations are analyzed as well. During the design of overall process flow for refinery, several issues including enlarging refinery scale and processing various sources of crude, processing unconventional extra-heavy crude, conflict requirement between increase gasoline production and chemical feedstock supply, production of low sulfur products, and integration of oil and coal, should take into account, in this paper some feasible ideas and suggestions are proposed.