Abstract: The optimization and application of energy saving and consumption reduction measures for the conversion system of the 2nd hydrogen production unit in Karamay Petrochemical Company were introduced. By reducing the natural gas consumption in fuel gas, enhancing the recovery efficiency and utilization rate of residual heat from flue gas and reforming gas, as well as increase the amount of byproduct steam, the energy consumption of the unit was improved significantly, a 48 445.64 MJ/h reduction was obtained. The long-term running showed that the unit was operated smoothly and economically with all the qualities indexes in well control.