Abstract: In this paper, the operation status of the 1.4 Mt/a hydrocracking unit at Sinopec Shanghai Gaoqiao Company is discussed including matters occurred and might happen. The effect of processing high sulfur feed on the process conditions, equipment corrosion and product quality is analyzed, so that, some suggestions for maintaining long-term production are put forward. It can be seen that with appropriate revamping, this unit could process feed having sulfur mass fraction below 1.96%, yet it should avoid processing high sulfur and high acid feeds heavily, optimization of feed constitution is appreciated. Monitoring the corrosion of pipeline and equipment should be carried on routinely. When processing high sulfur feed, the sulfur content of tail oil should be checked more often to provide reference data for increasing the temperature of post treating catalyst.