Abstract: The AEL-, TON-, and FER-type molecular sieves with 10 MR pore structures were used as the catalysts, and their skeletal isomerization performance of n-butene into isobutene were studied. The effect of temperature and space velocity on the n-butenes conversion, isobutene selectivity and yield was discussed. The results show that the AEL- and FER-type molecular sieves are suitable for the industrial process of isobutene isomerized from n-butene. The AEL-type molecule sieve prefers to be operated at the high temperature and low space velocity mode, and the isobutene yield is 41.4% at a pressure of 0.25 MPa, a temperature of 450 oC and a space velocity of 4 h-1. Whereas the FER-type one prefers to be at the low temperature and high space velocity operation mode, and the maximum isobutene yield reaches 45.9% at a pressure of 0.25 MPa, a temperature of 350 oC and a space velocity of 6 h-1.