Abstract: AlSBA-15/HY composite molecular sieves were prepared by multi-hydrolysis and crystallization under high ratio of SiO2/H2O with recycling mother liquid. The preparation efficiency increases as twice as classic synthesis method, meanwhile the cost of raw material greatly drops and almost no wastes of acid and water are discharged. NiW/AlSBA-15/HY catalyst was then prepared by volume impregnation of AlSBA-15/HY with Ni-W solution and used in hydrocracking of Daqing vacuum gas oil in a 200ml one stage serial connection process. The results indicate that NiW /AlSBA-15/HY catalyst has high catalytic activity, good middle distillates selectivity and excellent object products. Under the test conditions: temperature of 383℃，pph of 12.5MPa, H2/oil of 1000, and Sv of 1.4h-1，the diesel yield is 52.85%, middle fraction selectivity 79.4%, potential aromatic of heavy naphtha 43.5% and BMCI of tail-oil 5.0.