Abstract: The effect of reaction temperature，pressure, hydrogen/hydrocarbon mole ratio and weight hourly space velocity (WHSV) on the SKI-400H catalyst performance was investigated in a fixed bed. Based on the results, the adjustment of process parameters of its industrial application was conducted. The results show that the catalyst activity is increased with increasing the reaction temperature or pressure or decreasing the hydrogen/hydrocarbon mole ratio and WHSV and the reverse is true for selectivity. Gradually increasing the reaction temperature or pressure can keep the catalyst activity stable in a certain period of operation, but higher temperature can make the selectivity of the catalyst decrease significantly. However, there is a little impact on the selectivity of the catalyst when reaction pressure increases.