Abstract: ME-1 hydrodesulfurization catalyst newly developed by FRIPP was sulfided and the MoS2 phase morphology of the sulfided catalyst was characterized by higher resolution transmission electron microscopy (TEM) and compared with a commercial reference catalyst MoCo/Al2O3 for selective desulfurization of gasoline. Their HDS activity and selectivity were evaluated by heavy gasoline HDS test. The TEM results show that the numbers of stacking layers of MoS2 particles of ME-1 catalyst are 3.0-6.0 and the reference catalyst is 5.0-10.0, which indicates the higher dispersion of active component of ME-1 catalyst than the compared one. The HDS evaluation results show that when the sulfur content reaches 10μg/g in the product, the reaction temperature of ME-1 catalyst is 10 ℃ lower than the compared catalyst, olefin saturated rate is reduced by 32.2%, the research octane number (RON) loss of the product is reduced by 1.6. The evaluation tests demonstrate that the ME-1 catalyst has a higher HDS activity and selectivity. The commercial application results of ME-1 catalyst show that the sulfur content of FCCN can be reduced from 466 μg/g to 9.7μg/g, RON loss of 1.75. It is showed that ME-1 catalyst can meet the need for production of "sulfur-free gasoline" with less octane number loss.