Abstract: A macro kinetic model of VGO hydrodesulfurization was established by VGO HDS test in a pilot plant hydrogenation unit (200mL fixed-bed) using RN-32V catalyst and VGO feed from the Qingdao refining and chemical Co., Sinopec. At the same time, a catalyst deactivation model based on the data of activity changes with operation time was founded. The verification test results show that the deactivation model can well predict the sulfur content of product at different operation time and the life span of catalyst. It is valuable for the operation of hydrogenation unit.