Abstract: The hydroisomerization reactions of alkanes, single or mixed ones, with different structure on zeolite catalyst were studied. It is found that the chain lengths of alkanes have an obvious influence on the hydroisomerization selectivity of alkanes and that there is a mutual influence on isomerization reaction even between alkanes with different chain length and between normal and iso-alkanes. The data show that the longer the chain of the alkane, the more difficult to reduce the pour point of the alkane. The results indicate that long-chain n-alkanes can influence the reaction activity of the short-chain ones. The iso-alkanes in the mixed feed only influence the isomerization reactivity of the n-alkanes, but have an impact on the product distribution. At close conversion rate, the iso-product distribution of mixed material is more beneficial to reduce the pour point than that of the individual alkane.