Abstract: The catalyst deactivation during the HDM process can be divided into 3 stages. Based on the operation data of vacuum residue hydrogenation in STRONG ebullated bed, a catalyst deactivation kinetic model was established and then verified. The results show that in the initial stage, the reaction temperature accelerates catalyst deactivation and in the mid-term operation the activity of catalyst mainly depends on metal deposition. The verification test proves that the model fits well with the experiment data, indicating the good reliability and accuracy of the model for residue HDM catalyst deactivation in ebullated bed.