Abstract: Oxidative desulfurization of benzothiophene（BT，DBT and 4,6-DMDBT） in simulated oil was investigated using hydrogen peroxide as oxidant, Span60 as emulsifier, N-Methyl pyrrolidone as extractant and phosphotungstic acid/semi-coke (HPW/Sc) as catalyst. The catalysts of phosphotungstic acid (HPW)/semi-coke (Sc) were characterized by FTIR. The effect of HPW loading amount, reaction temperature, reaction time, and aromatics, olefins and nitrogen compounds on desulfurization rate was studied. The results show that the sulfur removal efficiency of DBT reaches above 99% using the catalyst with 30% HPW loading at the conditions of temperature of 60 ℃, reaction 60 min, amount of catalyst 1.0%, n(H2O2)/ n(S)=3, amount of Span60 emulsifier 0.36%，and the oxidative activity of the model sulfur compounds follows the order of DBT＞4,6-DMDBT＞BT. The benzene in the test oil can promote DBT desulfurization, while quinoline and cyclohexene inhibit the removal of DBT.