Abstract: Based on the characterization and hydrotreating reactivity of Yichang residue, a new hydrotreating catalyst for reduction of Conradson carbon residue (HDCCR) was developed by adopting Ni-Mo active metals and optimizing pore structure of the supports and adjusting the impregnation process, and adding promoter. The experimental results show that the residue hydrotreating layered catalyst system with the new HDCCR catalyst displays the higher HDCCR, HDS and HDN activities compared with the system with original HDCCR Co-Mo catalyst. Under the same reaction conditions, the Carbon residue reduced rate increases by 3.3%, HDN rate increases 7.9%. It is found that high reaction temperature, high hydrogen partial pressure and low volume space velocity improves HDCCR, HDS and HDN activities and thus improves the hydrotreated residue quality.