Abstract: Scheduling of crude oil operations is the first step of the refinery operations, which decides the subsequence process management. Based on the information of vessels, berths, terminal storage tanks, pipelines, factory tanks and crude distillation units of the refinery system and the consideration of the actual operation, like terminal tanks of single store, the feed quality requirements for the distillation units, et al, a blended crude transportation scheduling model was established based on asynchronous time characterization. Taking a typical domestic coastal oil refinery as an example, the feasibility of the model and solution efficiency was validated. The proposed model can obtain the optimal scheme in a short time despite the large scale of the model, which ensures the reasonable operations of terminal storage tanks, pipelines, factory tanks, fully shorten the delay shipping date and unloading time, and satisfies the requirements for smooth running of the crude distillation units, and realizes critical operation. The practical values of this scheduling model are worthy of being appreciated.