关键词: 吗啉乙醇, 吗啉, 环氧乙烷, 微通道反应器, 强放热反应

Abstract: In order to solve the problems of the synthesis of morpholine ethanol from morpholine and ethylene oxide, such as low yield, long reaction time, poor safety and the use of catalysts, in a microchannel reactor consisting of SIMM-V2 micro-mixer and a stainless steel tube, the continuous and rapid preparation of morpholine ethanol was studied, and the effects of reaction temperature, residence time, system pressure, molar ratio of raw materials and flow rate were investigated. The results showed that the yield of the reactor was almost equal comparable to that of the kettle reactor under the condition of no catalyst and shorter reaction time. With the increase of reaction temperature, residence time, and molar ratio, the yield of the product increased first and then decreased, there was a wide window of reaction conditions, that was, given a certain condition, the other conditions could be adjusted to obtain the same yield. Under typical reaction conditions, such as a temperature of 150 ℃, a morpholine to ethylene oxide molar ratio of 1:1.08, a residence time of 3 min, a total flow rate of 1 mL/min, and a system pressure of 2.5 MPa, the conversion of morpholine could reach 99.55%, and the selectivity of morpholine ethanol was 97.1%, which was much higher than that of the batch reaction.

Key words: morpholine ethanol, morpholine, ethylene oxide, microchannel reactor, strong exothermic reaction