Abstract: In order to meet the requirement of processing high nitrogen and sulfur feedstocks, a new generation of hydrocracking pretreatment catalyst, FF-46, was developed by Fushun Research Institute of Petroleum and Petrochemicals. FF-46 catalyst having Mo-Ni active metal components was prepared by complexation technology and the acidity of its support was well adjusted. Lab evaluation results showed that the catalytic activity of FF-46 catalyst was significantly better than those of other catalysts including an industrial reference catalyst. FF-46 catalyst was applied in several hydrocracking units successfully. The industrial application results showed that FF-46 catalyst exhibited high HDN and HDS activities，it can meet the requirement of long-term operation.